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Reflectance confocal microscopy (RCM) is a non-invasive imaging technique that provides real-time visualization of the skin, particularly the epidermis and upper dermis [1,2]. It is especially valuable for diagnosing and monitoring skin lesions, particularly when traditional methods like dermoscopy fall short [3]. However, RCM\'s diagnostic accuracy can be compromised by inflammatory infiltrates, leading to false-positive or false-negative results [4,5]. This study examines whether a short-term topical treatment with fusidic acid and betamethasone can improve RCM's diagnostic accuracy by reduc...