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There is an increasing incidence of melanoma worldwide, as well as the occurrence of systemic and locoregional metastases in advanced stages of disease. Although imaging studies have been performed to visualize the vasculature of melanoma, there are few studies and case reports addressing LC-OCT imaging of vascular morphology under local immunotherapy in melanoma and its skin metastases. Against this background, the present case report used LC-OCT (Line-field confocal optical coherence tomography) to visualize and analyze the changes in vascular morphology and blood flow of melanoma skin metas...